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KMID : 0363220080460101419
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Korean Journal of Dermatology
2008 Volume.46 No. 10 p.1419 ~ p.1423
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A Case of CD30 (+)/ALK (-) Primary Systemic Anaplastic Large Cell Lymphoma with Atypical Clinical Features
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Yang Yun-Seok
Kim Nack-In
Cho Hee-Ryung
Jeong Ki-Heon
Haw Choong-Rim
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Abstract
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Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin’s lymphoma, and this tumor is predominantly
composed of large lymphoid cells that have a strong expression of CD30. Two major groups of ALCL have been
described. The first is a spectrum of CD30＋ lymphoproliferative disorders, including primary cutaneous ALCL and
lymphomatoid papulosis. The second is systemic nodal ALCL, which can be subdivided into two groups: anaplastic
lymphoma kinase (ALK)-positive and ALK-negative. The relative frequency of ALCL in Korea is about 19% of all
cutaneous lymphomas. Solitary or multiple large nodular tumoral lesions confined to one body compartment are the
most common presentation. We report here on a case of CD30 (＋)/ALK ( ) primary systemic ALCL in a 77
year-old-male, and the skin lesion manifested as multiple papules, plaques and tumors on the trunk, buttocks and
upper and lower extremities.
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KEYWORD
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ALK, Anaplastic Large cell Lymphoma, CD30, Primary systemic ALCL
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